Synthesis and pharmacological activities of Schiff bases with some transition metal complexes: a review

AbstractSchiff bases transition metal complexes have received significant attentions in the scientific community for their versatile applications. The incorporation of metals to Schiff base ligands attracts much attention, since the metals and Schiff base ligands coordinated via bonding. Thus, chelation effects will enhance and improve the biological activities of the derivatives of title compound. Most of these derivatives displayed broad range bioactivities including antibacterial, antifungal, antituberclosis, antimalarial, antioxidant, antidiabetic, anti-inflammatory and anticancer activities. Up to date, continuous efforts are being made in various research groups to design the outcomes of more potent, novel and safe synthetic protocols towards the Schiff base metal complexes. Therefore, this review summarizes the various synthetic protocols and pharmacological activities of Schiff base metal complexes and their derivatives. Here, the synthesis of Schiff base ligands and their complexes with metals Cu(II), Pt(II), Ni(II), Pd(II), Ru(II, III), V(III), Cd (II), Zn(II), Co(II, III) and Mn(II, III) will be presented (2013 –2022).
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research