Exosome-Mediated Impact on Systemic Metabolism

Annu Rev Physiol. 2024 Feb 12;86:225-253. doi: 10.1146/annurev-physiol-042222-024535.ABSTRACTExosomes are small extracellular vesicles that carry lipids, proteins, and microRNAs (miRNAs). They are released by all cell types and can be found not only in circulation but in many biological fluids. Exosomes are essential for interorgan communication because they can transfer their contents from donor to recipient cells, modulating cellular functions. The miRNA content of exosomes is responsible for most of their biological effects, and changes in exosomal miRNA levels can contribute to the progression or regression of metabolic diseases. As exosomal miRNAs are selectively sorted and packaged into exosomes, they can be useful as biomarkers for diagnosing diseases. The field of exosomes and metabolism is expanding rapidly, and researchers are consistently making new discoveries in this area. As a result, exosomes have great potential for a next-generation drug delivery platform for metabolic diseases.PMID:38345906 | DOI:10.1146/annurev-physiol-042222-024535

Source: Physiological Reviews - February 12, 2024 Category: Physiology Authors: Karina Cunha E Rocha Wei Ying Jerrold M Olefsky Source Type: research