Blood and bones: Mechanical cues and Hippo signaling drive vascular invasion during limb formation

Dev Cell. 2024 Jan 22;59(2):173-174. doi: 10.1016/j.devcel.2023.12.008.ABSTRACTAlthough mechanical cues are known to influence the postnatal skeleton, the impact of bone cell mechano-transduction on early skeletal development remains less clear. In this issue of Developmental Cell, Collins et al. (2023) report that YAP/TAZ deletion in osteoblast precursors reduces Cxcl12 expression, leading to defects in bone vascularization.PMID:38262346 | DOI:10.1016/j.devcel.2023.12.008

Source: Developmental Cell - January 23, 2024 Category: Cytology Authors: Marc N Wein Source Type: research