Novel delivery systems for controlled release of bacterial therapeutics

Trends Biotechnol. 2024 Feb 2:S0167-7799(24)00002-7. doi: 10.1016/j.tibtech.2024.01.002. Online ahead of print.ABSTRACTAs more is learned about the benefits of microbes, their potential to prevent and treat disease is expanding. Microbial therapeutics are less burdensome and costly to produce than traditional molecular drugs, often with superior efficacy. Yet, as with most medicines, controlled dosing and delivery to the area of need remain key challenges for microbes. Advances in materials to control small-molecule delivery are expected to translate to microbes, enabling similar control with equivalent benefits. In this perspective, recent advances in living biotherapeutics are discussed within the context of new methods for their controlled release. The integration of these advances provides a roadmap for the design, synthesis, and analysis of controlled microbial therapeutic delivery systems.PMID:38310020 | DOI:10.1016/j.tibtech.2024.01.002

Source: Trends in Biotechnology - February 3, 2024 Category: Biotechnology Authors: Nadia Zaragoza Grace I Anderson Stephanie Allison-Logan Kirmina Monir Ariel L Furst Source Type: research