Single step synthesis of β- and γ- aryl-substituted ß- and γ-amino acid derivatives by electrochemistry

Bioorg Med Chem Lett. 2024 Jan 9;100:129614. doi: 10.1016/j.bmcl.2024.129614. Online ahead of print.ABSTRACTElectrochemical transformations are a subject of increasing interest in early drug discovery due to its ability to assemble complex scaffolds under rather mild reaction conditions. In this context, we became interested in electrochemical decarboxylative cross-coupling (DCC) protocols of redox-active esters (RAEs) and halo(hetero)arenes. Starting with the one-step electrochemical synthesis of novel methylamino-substituted heterocycles we recognized the potential of this methodology to deliver a novel approach to β- and γ- amino acids by starting from the corresponding RAEs. Our work finally resulted in the delivery of novel and highly valuable trifunctional building blocks based on ß- and γ-amino-acid scaffolds.PMID:38199329 | DOI:10.1016/j.bmcl.2024.129614

Source: Bioorganic and Medicinal Chemistry Letters - January 10, 2024 Category: Chemistry Authors: Barbara Pavlovic Christoph Heubel Michael Kurz Elisabeth Oehl Siegfried R Waldvogel Maria M éndez Sven Ruf Source Type: research