Numerical investigation of acoustic cavitation and viscoelastic tissue deformation

Ultrason Sonochem. 2024 Jan;102:106757. doi: 10.1016/j.ultsonch.2024.106757. Epub 2024 Jan 9.ABSTRACTAcoustic cavitation and tissue deformation are studied by modifying a level-set method for compressible two-phase flows to consider viscoelastic tissue deformation. The numerical simulations performed using different shear moduli and bubble-tissue distances demonstrate various interactions between bubble and viscoelastic tissue, including inverted cone-shape bubbles, bubble migration, liquid jet formation, compressive and expansive tissue deformation, and tissue perforation. The bubble is observed to grow larger with increasing tissue bulk modulus and density. The maximum tissue deformation generally increases with decreasing initial bubble-tissue distance and with increasing tissue bulk modulus and density. The tissue shear modulus conditions that maximize tissue deformation are in the range of 1-10 MPa, unless the tissue density is very large.PMID:38217908 | PMC:PMC10825659 | DOI:10.1016/j.ultsonch.2024.106757

Source: Ultrasonics Sonochemistry - January 13, 2024 Category: Chemistry Authors: Jaesung Park Gihun Son Source Type: research