Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling

Trends Biochem Sci. 2024 Jan 16:S0968-0004(24)00001-X. doi: 10.1016/j.tibs.2024.01.001. Online ahead of print.ABSTRACTRecent advances in cryo-electron microscopy (Cryo-EM) have revolutionized our understanding of the complement C5a/C3a receptors that are crucial in inflammation. A recent report by Yadav et al. has elucidated the activation, ligand binding, selectivity, and signaling bias of these receptors, thereby enhancing structure-guided drug discovery. This paves the way for more effective anti-inflammatory therapies that target these receptors with unprecedented precision.PMID:38233283 | DOI:10.1016/j.tibs.2024.01.001

Source: Trends in Biochemical Sciences - January 17, 2024 Category: Biochemistry Authors: Francisco J Fern ández M Cristina Vega Source Type: research