High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry

In conclusion, our CYP cocktail inhibition assay can detect CYP3A activation and assess the direct and time-dependent inhibition potentials for CYP3A, CYP2C9, and CYP2D6. This method is expected to be very efficient in the early stages of drug discovery.PMID:38265764 | DOI:10.1080/00498254.2024.2308818

Source: Xenobiotica - January 24, 2024 Category: Research Authors: Yu Yumoto Takuro Endo Hiroshi Harada Kaoru Kobayashi Takeshi Nakabayashi Yoshikazu Abe Source Type: research