Drug-drug co-amorphous systems: An emerging formulation strategy for poorly water-soluble drugs

Drug Discov Today. 2024 Feb;29(2):103883. doi: 10.1016/j.drudis.2024.103883. Epub 2024 Jan 14.ABSTRACTOvercoming the poor water solubility of small-molecule drugs is a major challenge in the development of clinical pharmaceuticals. Amorphization of crystalline drugs is a highly effective strategy to improve their aqueous solubility. However, amorphous drugs are thermodynamically unstable and likely to crystallize during manufacturing and storage. Recently, drug-drug co-amorphous systems have emerged as a novel strategy to not only enable enhanced dissolution and physical stability of the individual drugs within the system but also to provide a strategy for combination therapy of the same or different clinical indications. This review serves to highlight advances in the methods used to manufacture and characterize drug-drug co-amorphous systems, summarize drug-drug co-amorphous applications reported in recent decades, and provide an outlook on future possibilities and perspectives.PMID:38219970 | DOI:10.1016/j.drudis.2024.103883
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Source Type: research