Nicholas Reactions of Pentadiynyl –Co2(CO)6 Cations. Synthesis of Antimalarial Hinokiresinol Analogues

Synthesis DOI: 10.1055/a-2250-8050 Penta-1,4-diyn-3-ol–Co2(CO)6 complexes undergo Lewis acid mediated Nicholas reactions with high selectivity at the C-3 site, to give skipped (1,4-)diyne complexes. The compatible nucleophiles have a wide range of reactivity. The methodology has been applied to the synthesis of both (E)- and (Z)-isomers of a hinokiresinol and nyasol analogue, the (E)-isomer of which is known to have elevated antiplasmodial and antimalarial activity. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - February 14, 2024 Category: Chemistry Authors: Muresan, Marcus Green, James R. Tags: paper Source Type: research