Synthesis of spiropyridazine-benzosultams by the [4 + 2] annulation reaction of 3-substituted benzoisothiazole 1,1-dioxides with 1,2-diaza-1,3-dienes

Abstract
A simple and efficient method for the synthesis of spiropyridazine-benzosultams has been developed by means of [4 + 2] annulation reaction of 3-substituted benzoisothiazole 1,1-dioxides with 1,2-diaza-1,3-dienes. This approach displays advantages such as mild reaction conditions, wide substrate range tolerance, simple operation, compatibility with gram-scale preparation.

Beilstein J. Org. Chem. 2024, 20, 280–286. doi:10.3762/bjoc.20.29

Source: Beilstein Journal of Organic Chemistry - February 14, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: [4 2] annulation reaction 1,2-diaza-1,3-dienes spiro-benzosultams 3-substituted benzoisothiazole 1,1-dioxides Full Research Paper Source Type: research