Influence of study characteristics, methodological rigour and publication bias on efficacy of pharmacotherapy in obsessive-compulsive disorder: a systematic review and meta-analysis of randomised, placebo-controlled trials

Conclusions
Our findings reveal superiority of clomipramine over SSRIs, even after adjusting for risk of bias. Effect sizes may be attenuated when considering publication bias and methodological rigour, emphasising the importance of robust studies to guide clinical utility of OCD pharmacotherapy.

PROSPERO registration number
CRD42023394924.

Source: Evidence-Based Mental Health - February 12, 2024 Category: Psychiatry & Psychology Authors: Cohen, S. E., Zantvoord, J. B., Storosum, B. W. C., Mattila, T. K., Daams, J., Wezenberg, B., de Boer, A., Denys, D. A. J. P. Tags: Open access Pharmacological treatments Source Type: research