Solvent-Free Efficient Synthesis of New 4-Thiazolidinones with a Fructose Scaffold through a Microwave-Assisted Cascade Multicomponent Reaction

Synthesis DOI: 10.1055/a-2231-4922 Using a chemoselective, sustainable and highly efficient method, new 4-thiazolidinones and 1,4-thiazepan-3-ones substituted with a glycosidic residue derived from d-fructose were synthesized. Microwave-assisted cascade multicomponent reaction under solvent-free conditions gave very good yields in short reaction times, which was followed by a nontoxic purification method of one of the diastereomers by precipitation–centrifugation. The new purified compounds isolated as diastereomers were evaluated as factor Xa (FXa) inhibitors. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - February 12, 2024 Category: Chemistry Authors: Lorenzo, Fernando Ocampo, Romina Rodr íguez, Diego F. Santana-Romo, Fabi án Galdamez, Antonio Zacconi, Flavia C. Burrow, Robert A. Mandolesi, Sandra D ’Accorso, Norma Tags: paper Source Type: research