Copper-Catalyzed Enantioselective Radical Esterification of Propargylic C –H Bonds

Synthesis DOI: 10.1055/a-2240-5349 The copper-catalyzed enantioselective radical esterification of propargylic C–H bonds with tert-butyl peroxybenzoate (TBPB) as an oxidizing agent and an oxygenated nucleophile is reported. This variant of the Kharasch–Sosnovsky oxidation allows for the asymmetric esterification of open-chain carbon radicals without excessive amounts of alkyne substrates under mild reaction conditions, achieving a one-step conversion of simple alkynes into chiral propargylic esters. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - February 8, 2024 Category: Chemistry Authors: Xi, Jiajia Zhu, Xiaotao Bao, Hongli Tags: paper Source Type: research