Engineering megabase-sized genomic deletions with MACHETE (Molecular Alteration of Chromosomes with Engineered Tandem Elements)

Nature Protocols, Published online: 07 February 2024; doi:10.1038/s41596-024-00953-9The authors introduce MACHETE (molecular alteration of chromosomes with engineered tandem elements), a clustered regularly interspaced short palindromic repeats directed Cas9-based system for the efficient deletion of megabase-sized genomic regions.
Source: Nature Protocols - Category: Biomedical Science Authors: Source Type: research