Directing Hydrogen Isotope Exchange with Aryl Carboxylic Acids

Synlett DOI: 10.1055/a-2239-6965 A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - February 5, 2024 Category: Chemistry Authors: Mudd, Richard J. Reid, Marc Paterson, Laura C. Atzrodt, Jens Derdau, Volker Kerr, William J. Tags: letter Source Type: research