Modular Synthesis of 4-Acylquinolines via Cycloaddition of 1,3-Enynes and Nitrosoarenes

Synlett DOI: 10.1055/a-2229-1963 Herein, we disclose a FeBr2-promoted cycloaddition of readily available 1,3-enynes and nitrosoarenes, providing a promising platform for the synthesis of privileged 4-acylquinoline scaffolds. This simple, one-pot process is characterized by high atom-economy, broad substrate-scope, and excellent functional-group tolerance. A possible reaction mechanism was proposed, involving processes such as [4+2] cycloaddition, ring opening, aromatization, and dehydroaromatization. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - February 5, 2024 Category: Chemistry Authors: Li, Xiao Diao, Chenxin Kong, Wangqing Tags: letter Source Type: research