Deletion of Pak1 in CD11c positive cells confers resistance to mouse skin carcinogenesis

p21 (CdC42/RAC1)-activated kinases (PAKs) are implicated in the nodal point of several oncogenic signaling pathways. Indeed, the aberrant overexpression or mutational activation of PAK isoforms is frequently observed in numerous human tumors. Recent reports suggest that the enhanced PAK activity is a hallmark of many oncogenic cellular processes (Radu et al., 2014).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research