Receptor tyrosine kinase EPHA2 drives epidermal differentiation through regulation of EGFR signaling.

Intricate signaling systems are required to maintain homeostasis and promote differentiation in epidermis. Receptor tyrosine kinases are central in orchestrating these systems in epidermal keratinocytes. In particular, EPHA2 and EGFR transduce distinct signals to dictate keratinocyte fate, yet how these cell communication networks are integrated has not been investigated. Our work shows that loss of EPHA2 impairs keratinocyte stratification, differentiation, and barrier function. To determine the mechanism of this dysfunction, we drew from our proteomics data of potential EPHA2 interacting proteins.

Source: Journal of Investigative Dermatology - February 2, 2024 Category: Dermatology Authors: Bethany E. Perez White, Calvin J. Cable, Bo Shi, Rosa Ventrella, Nihal Kaplan, Aya Kobeissi, Yuya Higuchi, Abhinav Balu, Zachary R. Murphy, Priya Kumar, Spiro Getsios Tags: Original Article Source Type: research