Chiral phosphoric acid-catalyzed transfer hydrogenation of 3,3-difluoro-3H-indoles

Abstract
A convenient and efficient method for the synthesis of optically active difluoro-substituted indoline derivatives starting from the corresponding 3H-indoles by chiral phosphoric acid-catalyzed transfer hydrogenation was developed. Using Hantzsch ester as the hydrogen source under mild reaction conditions, the target products can be obtained with excellent yield and enantioselectivity.

Beilstein J. Org. Chem. 2024, 20, 205–211. doi:10.3762/bjoc.20.20

Source: Beilstein Journal of Organic Chemistry - February 1, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: asymmetric organocatalysis chiral Br ø nsted acid 3,3-difluoroindoline Hantzsch ester transfer hydrogenation Letter Source Type: research