Alumina-Promoted Copper-Catalyzed Hydroboration of Alkynes

Synthesis DOI: 10.1055/a-2236-8874 Alumina was found to activate Cu(I) catalysts in hydroboration of alkynes. This allowed to develop a simple and efficient protocol for hydroboration of alkynes with B2Pin2 using inexpensive CuCl/PPh3 catalytic system. The approach does not require moisture-sensitive activators and stepwise preparation of ‘activated’ Cu complex. The developed conditions were applied to the preparation of β-styrylboronates from terminal and internal alkynes with excellent regio- and stereoselectivity. The procedure can also be extended to other terminal alkynes by the appropriate choice of ligand. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - January 31, 2024 Category: Chemistry Authors: Barashkova, Xenia A. Parulava, Mikhail J. Kotovshchikov, Yury N. Latyshev, Gennadij V. Lukashev, Nikolay V. Beletskaya, Irina P. Tags: paper Source Type: research