Aromatic Residue Positioning Influences Helical Peptoid Structure in Aqueous Solution

Synlett DOI: 10.1055/a-2238-5394 Water-soluble peptidomimetics, including peptoids, are promising functional surrogates for biologically relevant, amphiphilic, helical peptides. Twenty amphiphilic peptoid hexamers with predicted helical structures were designed, prepared, and studied using circular dichroism (CD) spectroscopy. The site-specific contributions of aromatic and charged residues to the helical structure of peptoid hexamers in aqueous solution was evaluated, revealing that aromatic residue positioning most significantly impacts structure. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text

Source: Synlett - January 30, 2024 Category: Chemistry Authors: Javed, Jwwad M. Scukas, Katherine Nguyen, Michelle T. Fuller, Amelia A. Tags: letter Source Type: research