Short Synthesis of Dopamine Agonist Rotigotine

Synthesis DOI: 10.1055/a-2235-5080 A practical and short synthesis of FDA approved drug, Rotigotine, is achieved in two steps from 5-methoxy-2-tetralone, which in turn was synthesised by [4+2] cycloaddition of the in situ generated methoxyaryne from its precursor aryl triflate with benzyloxybutadiene or from 4-methoxyindanone via ring expansion using trimethylsilyldiazomethane. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - January 29, 2024 Category: Chemistry Authors: Shekhar, Chandra Karmakar, Santanu Mainkar, Prathama S. Chandrasekhar, Srivari Tags: paper Source Type: research