Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation

AbstractIn the pursuit of discovering new active metabolites from helicosporous hyphomycetes, rice fermentation products ofNeohelicosporium griseum were examined. Eight compounds were isolated from this saprophytic fungus, namely vertixanthone (1), diaportheone A (2), 1,3,6,8-tetrahydroxyanthraquinone (3), lecanoric acid (4), decarboxycitrinone (5), 6,8-dihydroxy-4-hydroxymethyl-3,5-dimethyl-isochromen-1-one (6), decarboxyhydroxycitrinone (7), and ergosterin (8). The 1D and 2D NMR characteristics of compound1 in DMSO-d6 were detailed for the first time. Antimicrobial testing indicated that compounds1–4 exhibited moderate activity againstPseudomonas aeruginosa, with compound3 also showing weak activity againstStaphylococcus aureus. In-vitro cytotoxicity assays revealed that compounds1,3, and4 displayed cytotoxic activity against HELA cell lines, with respective IC50 values of 30.8, 13.7, and 14.1  µM. Compounds1,3, and4 also showed significant cytotoxicity against A549 cell lines, with respective IC50 values of 24.7, 7.4, and 10.3  µM.

Source: Medicinal Chemistry Research - January 27, 2024 Category: Chemistry Source Type: research