Reasons for failure of noninvasive prenatal test for cell ‐free fetal DNA in maternal peripheral blood

ConclusionsThe main reason for NIPT failure was the low ratio of cffDNA. Postponing the gestational weeks of blood collection may improve the success rate. Resampling and retesting upon informed consent in pregnant women who failed the first test could improve the success rate. For pregnant women who finally failed NIPT, it is suggested strengthening the genetic counseling, prenatal examination, and ultrasound evaluation, and carry out interventional prenatal diagnosis if necessary.

Source: Molecular Genetics & Genomic Medicine - January 19, 2024 Category: Genetics & Stem Cells Authors: Xiangsha Kong, Lin Zhang, Ruifeng Yang, Haiying Zhang, Meihong Ren, Xiang Wang, Ling Zhu, Hongsong Chen, Huiying Rao Tags: ORIGINAL ARTICLE Source Type: research