459 Common vaginal microbes modify Group B Streptococcus growth at epithelial barriers: potential mechanisms governing colonization

Group B Streptococcus (GBS) disease, the leading cause of early-onset neonatal sepsis, is predicated upon vaginal colonization. Given limitations of existing screening and prophylaxis strategies, primary prevention of GBS disease necessitates interventions targeting vaginal colonization. Features of vaginal ecosystems may modify GBS colonization though mechanisms are incompletely understood. We sought to investigate how common vaginal microbes modify GBS growth at epithelial barriers.

Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Briana Ferguson, Dylan Curry, Elliot Friedman, Jennifer A. McCoy, Paul J. Planet, Dustin Flannery, Karen Puopolo, Lauren Anton, Kristin D. Gerson Source Type: research