Neutrophilic Dermatoses: A Medley of Inflammatory Cutaneous and Systemic Disorders

Before coining of the term “neutrophilic dermatosis” by a British dermatologist Dr Robert Sweet1 in 1964, inflammatory cutaneous conditions with heterogenous presentations, often having systemic associations, were reported. Over time, due to the aseptic infiltration of neutrophils in the skin, subcutaneous tissue, and oth er organs, this grouping of disorders as neutrophilic dermatoses (NDs) became commonly accepted. Dr Louis Brocq2,3 of France first described a form of cutaneous ulceration that we now call pyoderma gangrenosum (PG) as “geometric phagedenism.” Dr Thomas Cullen4 from Johns Hopkins reported a form of progressive postoperative “gangrene” of the skin in 1924 that was later termed postoperative or postsurgical PG, while Drs Louis Brunsting, William Goeckerman, and Paul Oleary5 from the Mayo Clinic coined the term “pyoderma (ecthyma) gangrenosum” in 1930.
Source: Dermatologic Clinics - Category: Dermatology Authors: Tags: Preface Source Type: research