Radiosynthesis of α-[18F]Fluoroamides with [18F]AgF

Synlett DOI: 10.1055/s-0041-1738458 A silver-promoted nucleophilic radiofluorination of α-bromoamides has been developed for the radiosynthesis of α-[18F]fluoroamides. The reaction conditions are straightforward and compatible with primary, secondary, and tertiary α-bromoamides. Furthermore, the methodology has been successfully applied to the synthesis of bioactive radiotracers with good radiochemical conversion (RCC) and radiochemical yield (RCY). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - January 15, 2024 Category: Chemistry Authors: Gong, Kehao Yin, Zhengxu Song, Pengfei Xu, Bo Han, Junbin Tags: letter Source Type: research