Nickel-Catalyzed Synthesis of Benzylamines from (Hetero)aryl Halides and Glycine-Derived N-Hydroxyphthalimide Esters

Synlett DOI: 10.1055/s-0043-1763656 A nickel-catalyzed aminomethylation of aryl or heteroaryl iodides or bromides for the preparation of protected primary benzylamines is reported. This cross-electrophile reductive protocol engages carbamate-protected, glycine-derived N-hydroxyphthalimide (NHP) esters in an efficient decarboxylative cross-coupling in only two hours. The catalyst and NHP ester reagents are commercially available or can be synthesized in one step on a decagram scale with no chromatography. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - January 12, 2024 Category: Chemistry Authors: Choi, Eun Seo Rousseaux, Sophie A. L. Huestis, Malcolm P. Tags: letter Source Type: research