Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis

Acne keloidalis (AK) is a primary scarring alopecia characterized by longstanding inflammation in the scalp causing keloid-like scar formation and hair loss. Histologically, AK is characterized by mixed leukocytic infiltrates in the acute stage followed by a granulomatous reaction and extensive fibrosis in the later stages. To further explore its pathogenesis, bulk RNA-sequencing, single-cell RNA-sequencing, and spatial transcriptomics were applied to occipital scalp biopsy specimens of lesional and adjacent non-lesional skin in patients with clinically active disease.

Source: Journal of Investigative Dermatology - January 11, 2024 Category: Dermatology Authors: Yi-Kai Hong, Daw-Yang Hwang, Chao-Chun Yang, Siao Muk Cheng, Peng-Chieh Chen, Wilson Jr Aala, Hans I ‐Chen Harn, Spencer T. Evans, Alexandros Onoufriadis, Si-Lin Liu, Yu-Chen Lin, Yi-Han Chang, Tzu-Kun Lo, Kuo-Shu Hung, Yi-Chao Lee, Ming-Jer Tang, Kurt Tags: Original Article Source Type: research