A guide to the use of bioassays in exploration of natural resources
We present a comprehensive list of practical considerations for selecting appropriate bioassays and discuss in detail the bioassays typically used to explore antimicrobial, antibiofilm, cytotoxic, antiviral, antioxidant, and anti-ageing potential. The concept of quality control and bioassay validation are introduced, followed by safety considerations, which are critical to advancing bioactive compounds to a higher stage of development. We conclude by providing an application-oriented view focused on the development of pharmaceuticals, food supplements, and cosmetics, the industrial pipelines where currently known marine natural products hold most potential. We highlight the importance of gaining reliable bioassay results, as these serve as a starting point for application-based development and further testing, as well as for consideration by regulatory authorities.PMID:38185432 | DOI:10.1016/j.biotechadv.2024.108307
Source: Biotechnology Advances - Category: Biotechnology Authors: Jerica Saboti č Engin Bayram David Ezra Susana P Gaud êncio Berat Z Haznedaro ğlu Nika Jane ž Leila Ktari Anna Luganini Manolis Mandalakis Ivo Safarik Dina Simes Evita Strode Anna Toru ńska-Sitarz Despoina Varamogianni-Mamatsi Giovanna Cristina Vares Source Type: research
More News: Antidoxidants | Biotechnology