E.  coli´s fight against TYROnny: Designing a bacterial strain to tackle tyrosinemia type 1

Tyrosinemia type 1 (HT-1) is a rare autosomal recessive disease caused by a deficiency of fumarylacetoacetate hydrolase (FAH)1,2 and occurs in approximately 1 in 100,000 newborns.3 The lack of FAH leads to an increase in intermediary products of the degradation of phenylalanine and tyrosine to fumarate and acetoacetate2 (Fig.  1A). Next to the name-giving increase of tyrosine levels in the sera of patients suffering from this disease, an elevation of fumarylacetoacetate (FAA), the direct substrate of FAH, can be detected2 (Fig. 1B).

Source: Journal of Hepatology - November 23, 2023 Category: Gastroenterology Authors: J öran Lücke, Samuel Huber Tags: Editorial Source Type: research