In silico method to maximise the biological potential of understudied metabolomic biomarkers: a study in pre-eclampsia

This study pointed to a long-standing issue in metabolomic studies. The lack of robust strategies for biomarker discovery would leave readers with the impression that ‘the biomarker is out-of-nowhere but works’, especially in those scarcely studied biomarkers. Herein, we provided a strategy that infers the potential of understudied biomarkers for further investigation. A previous study has shown that gut bacterial dysbiosis can cause pre-eclampsia (PE) symptoms through the gut–placenta axis.3 However, the role and potential therapeutic effect of gut metabolites as key mediators between bacteria and host remain elusive in PE. Thus, we assessed the faecal metabolome in an age-matched case–control study to complete the theory of the gut–placenta axis and identify metabolites with therapeutic potential for PE. For metabolites depleted in...

Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Zheng, H., Mai, F., Zhang, S., Lan, Z., Wang, Z., Lan, S., Zhang, R., Liang, D., Chen, G., Chen, X., Feng, Y. Tags: Gut PostScript Source Type: research