Neutrophil-derived microRNA-1290 promotes keratinocyte proliferation in psoriasis

The pathological hallmark of psoriasis is the infiltration of neutrophils into the skin. Some neutrophil-derived microRNAs (miRNAs) serve as biomarkers for various diseases, but none have been reported for psoriasis. Here, we investigated the involvement of miRNAs released from neutrophils in psoriasis pathogenesis. We compared the expression of miRNAs in the sera of patients with psoriasis and healthy individuals and found that the expression of two miRNAs, miR-223 and miR-1290, was significantly upregulated in the sera of patients with psoriasis.

Source: Journal of Investigative Dermatology - December 27, 2023 Category: Dermatology Authors: Yuko Higashi, Munekazu Yamakuchi, Atsuko Ibusuki, Aoi Okubo, Tomoko Fukushige, Teruto Hashiguchi, Takuro Kanekura Tags: Original Article Source Type: research