Real-time definition of single seed placement sensitivity in low-dose-rate prostate brachytherapy

PURPOSE: In low-dose-rate brachytherapy, iodine-125 seeds are implanted based on a treatment plan, generated with respect to different dose constraints. The quality of the dose distribution depends on a precise seed placement, however, during treatment planning the impact on the dose parameters when certain seeds fail to be placed precisely is not clear. METHODS AND MATERIALS: We developed a method using automatic differentiation to calculate gradients of dose parameters with regard to the seeds ’ positions.

Source: Brachytherapy - December 23, 2023 Category: Cancer & Oncology Authors: Katharina I. Jerg, Ernest Chukwudi N. Okonkwo, Frank A. Giordano, Yasser Abo-Madyan, Felix Momm, J ürgen W. Hesser Tags: Original Article Source Type: research