Unbiased interrogation of functional lysine residues in human proteome

Bao et  al. establish a CRISPR strategy for unbiasedly probing functional amino acid residues at the genome scale. They systematically survey the functional lysine residues that affect cell fitness. Novel mechanisms that govern the cell cycle via lysine residues are unraveled, and clinically significant l ysine mutations are identified.

Source: Molecular Cell - November 22, 2023 Category: Cytology Authors: Ying Bao, Qian Pan, Ping Xu, Zhiheng Liu, Zhixuan Zhang, Yongshuo Liu, Yiyuan Xu, Ying Yu, Zhuo Zhou, Wensheng Wei Tags: Resource Source Type: research