m6A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3

Shan et  al. discovered that the m6A-IGF2BP3 axis regulates mRNA partitioning in HeLa cells. mRNAs enriched in the P-bodies are hyper-m6A-methylated, whereas those associated with polysomes are less methylated. Loss of m6A switches mRNAs from P-bodies to polysomes, whereas the m6A reader IGF2BP3 can drive target mRNAs to P-bodies.

Source: Molecular Cell - November 27, 2023 Category: Cytology Authors: Ting Shan, Feiyan Liu, Miaomiao Wen, Zonggui Chen, Shaopeng Li, Yafen Wang, Hong Cheng, Yu Zhou Tags: Article Source Type: research