Application of a 3D bioprinter: jet technology for 'biopatch' development using cells on hydrogel supports

Biotechniques. 2023 Dec 12. doi: 10.2144/btn-2023-0052. Online ahead of print.ABSTRACTAdditive manufacturing (3D printing) has been deployed across multiple platforms to fabricate bioengineered tissues. We demonstrate the use of a Thermal Inkjet Pipette System (TIPS) for targeted delivery of cells onto manufactured substrates to design bio-bandages. Two cell lines - HEK 293 (kidney) and K7M2 wt (bone) - were applied using TIPS. We demonstrate a novel means for targeted cell delivery to a hydrogel support structure. These cell/support constructs (bio-bandages) had a high viability for survival and growth over extended periods. Combining a flexible biosupport with application of cells via TIPS printing now for the first time allows for custom cell substrate constructs with various densities to be deployed for regenerative medicine applications.PMID:38084384 | DOI:10.2144/btn-2023-0052
Source: BioTechniques - Category: Biotechnology Authors: Source Type: research