Chiral Bifunctional NHC –Guanidine Ligands for Asymmetric Hydrogenation

We report the synthesis of chiral N-heterocyclic carbene/guanidine bifunctional ligands from readily available amino alcohols. The resulting chiral bifunctional copper(I) complexes are active catalysts in an asymmetric hydrogenation of ketones. We show that the chiral linker unit can be employed for the transfer of stereoinformation. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - December 14, 2023 Category: Chemistry Authors: Gorai, Mahadeb Teichert, Johannes F. Tags: letter Source Type: research