Bidentate Lewis Acid-Catalyzed Inverse Electron-Demand Diels –Alder Reaction of Phthalazines and Cyclooctynes

Synlett DOI: 10.1055/a-2204-9522 Herein we report a method for facilitating the inverse-electron-demand Diels–Alder reaction of 1,2-diazines and cyclooctynes by utilizing a boron-based bidentate Lewis acid catalyst. Readily available electron-deficient and electron-rich phthalazines proved to be suitable substrates in this transformation. The described method enables the facile construction of diversely substituted polycyclic aromatic hydrocarbons fused to eight-membered carbocycles. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - December 13, 2023 Category: Chemistry Authors: Gro ße, Michel Wegner, Hermann A. Tags: letter Source Type: research