Hydrogen Sulfate-Templated Synthesis of a Bis-Ferrocene Macrocycle

Synlett DOI: 10.1055/s-0043-1763628 A bis-ferrocene macrocycle was synthesized by reversible acylhydrazone formation under thermodynamic control, starting from a ferrocene functionalized with hydrazide and protected aldehyde moieties. A hydrogen sulfate anion acts as a template to direct the synthesis specifically toward the macrocyclic dimer, due to a weak but selective binding interaction. This work highlights the utility of dynamic combinatorial chemistry as an approach to macrocycle synthesis. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - December 13, 2023 Category: Chemistry Authors: Beeren, Sophie R. Tags: letter Source Type: research