Integrative Keratinocyte Responses to TWEAK with IL-13 and IL-22 Reveal Pathogenic Transcriptomes Associated with Atopic Dermatitis

Atopic dermatitis (AD) is characterized by dysregulated activity of keratinocytes, and IL-13 and IL-22 are considered drivers of disease in part through stimulating these cells (Facheris et al., 2023, Kim et al., 2019, Humeau et al., 2022). Whether these cytokines act independently or with other inflammatory molecules is not clear. Previously, we reported that mice deficient in the cytokine TWEAK (tumor necrosis factor-related weak inducer of apoptosis; TNFSF12) were resistant to developing experimental AD, with its receptor Fn14 (TNFRSF12A) prominently expressed on keratinocytes (Sidler et al., 2017).

Source: Journal of Investigative Dermatology - December 8, 2023 Category: Dermatology Authors: Rinkesh K. Gupta, Kai Fung, Daniela Salgado Figueroa, Ferhat Ay, Michael Croft Tags: Letters to the Editor Source Type: research