K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution

Reactive aldehydes are produced by cellular metabolism and accumulate in human tissues if aldehyde clearance mechanisms are impaired. Suryo Rahmanto, Blum et  al. demonstrate that formaldehyde induces RNA-protein crosslinks (RPCs) that stall the ribosome and inhibit translation in human cells. The resolution of RPCs is regulated by scarcely studied K6-linked ubiquitylation assembled by an evolutionary conserved E3 ligase.

Source: Molecular Cell - November 9, 2023 Category: Cytology Authors: Aldwin Suryo Rahmanto, Christian J. Blum, Claudia Scalera, Jan B. Heidelberger, Mikhail Mesitov, Daniel Horn-Ghetko, Justus F. Gr äf, Ivan Mikicic, Rebecca Hobrecht, Anna Orekhova, Matthias Ostermaier, Stefanie Ebersberger, Martin M. Möckel, Nils Krapot Tags: Article Source Type: research