Tree-based QTL mapping with expected local genetic relatedness matrices

We identify quantitative trait loci by testing the eGRM, a measure of local relatedness based on the ancestral recombination graph, for association with phenotypes using a variance-components framework. This is beneficial for phenotypes with allelic heterogeneity and allows us to capture untyped variation without imputation in understudied populations.

Source: The American Journal of Human Genetics - December 7, 2023 Category: Genetics & Stem Cells Authors: Vivian Link, Joshua G. Schraiber, Caoqi Fan, Bryan Dinh, Nicholas Mancuso, Charleston W.K. Chiang, Michael D. Edge Tags: Article Source Type: research