Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis

Conclusion
We revealed that a novel tripeptide, RKH, derived from live AKK, may act as a novel endogenous antagonist for TLR4. RKH may serve as a novel potential therapeutic approach to combat lethal sepsis after successfully translating its efficacy into clinical practice.

Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Xie, S., Li, J., Lyu, F., Xiong, Q., Gu, P., Chen, Y., Chen, M., Bao, J., Zhang, X., Wei, R., Deng, Y., Wang, H., Zeng, Z., Chen, Z., Deng, Y., Lian, Z., Zhao, J., Gong, W., Chen, Y., Liu, K.-X., Duan, Y., Jiang, Y., Zhou, H.-W., Chen, P. Tags: Editor's choice, Gut Gut microbiota Source Type: research