Internal Atom Exchange in Oxazole Rings: A Blueprint for Azole Scaffold Evaluation

Synlett DOI: 10.1055/a-2201-9285 In this article, we provide a route to transform isoxazoles and oxadiazoles into the corresponding pyrazoles and 1,2,4-triazoles in one step using catalytic amounts of an air-stable Ni(0) complex. The reaction is a formal atom-exchange process at the internal heteroatoms of the aromatic cycle. This work provides a blueprint for reactivity that permits the rapid evaluation of different five-membered azole scaffolds, thus avoiding de novo synthesis of the molecule of interest. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - December 4, 2023 Category: Chemistry Authors: Spinnato, Davide Leutzsch, Markus Wang, Feng Cornella, Josep Tags: letter Source Type: research