Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution

Synthesis DOI: 10.1055/a-2201-9951 A cascade, metal-promoted transformation utilizing chloro allenylamide, primary amine, and aryl iodide afforded piperizinones in good yields. Under the optimized conditions the cascade is performed as a one-pot process allowing the formation of three bonds. The synthetic route, controlled by the reaction rates of several processes involved, introduces two points of diversity and is well suited for combinatorial synthesis or related technologies. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - November 29, 2023 Category: Chemistry Authors: Petkovic, Milos Kusljevic, Du šica Jovanovic, Milos Jovanovic, Predrag Tasic, Gordana Simic, Milena Savic, Vladimir Tags: paper Source Type: research