A Convergent Approach for the Synthesis of C14 –C26 Fragment of Anticancer Drug Eribulin Mesylate

Synthesis DOI: 10.1055/a-2202-5597 The stereoselective synthesis of C14–C26 fragment of eribulin is reported in a convergent way by coupling of fragment C14–C19 with fragment C20–C26 that are accessible from commercially available raw materials crotonic acid and 1,4-butanediol. The key steps involved in this practical approach are Hosomi–Sakurai asymmetric alkylation, Maruoka allylation, Noyori reduction, silver-catalyzed one-pot rearrangement, and intramolecular cyclization. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - November 29, 2023 Category: Chemistry Authors: Nasam, Rajesh Pabbaraja, Srihari Tags: paper Source Type: research