Molecular medicinal insights into scaffold hopping-based drug discovery success

Drug Discov Today. 2023 Nov 25:103845. doi: 10.1016/j.drudis.2023.103845. Online ahead of print.ABSTRACTIn both academia and the pharmaceutical industry, innovative hypotheses, methodologies and technologies that can shorten the drug research and development, leading to higher success rates, are vital In this review, we demonstrate how innovative variations of the scaffold-hopping strategy have been used to create new druggable molecular spaces, drugs, clinical candidates, preclinical candidates, and bioactive agents. We also analyze molecular modulations that enabled improvements of the pharmacodynamic (PD), physiochemical, and pharmacokinetic (PK) properties (P3 properties) of the drugs resulting from these scaffold-hopping strategies.PMID:38013043 | DOI:10.1016/j.drudis.2023.103845

Source: Drug Discovery Today - November 28, 2023 Category: Drugs & Pharmacology Authors: Ayan Acharya Mukul Yadav Mithilesh Nagpure Sanathanalaxmi Kumarsan Sankar K Guchhait Source Type: research