Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis

Irisin plays a key role in metabolic diseases, including type 2 diabetes mellitus (T2DM). However, the mechanism underlying the link between irisin and the development of T2DM, particularly in pancreatic islet...

Source: Diabetology and Metabolic Syndrome - November 22, 2023 Category: Endocrinology Authors: Tianrong Li, Jingjing Yang, Anjun Tan and Hewen Chen Tags: Research Source Type: research